Quote:Codeine is an opioid pain-relief medicine used for the
short-term relief of mild to moderate pain.
It is
not usually recommended for the treatment of chronic (long-term) pain.
Codeine is only available on prescription from your doctor.
If you stop taking codeine suddenly, you may experience withdrawal symptoms.
https://www.healthdirect.gov.au/codeine Quote:Over time, you may develop tolerance to the effects of codeine. This means that your body needs more and more of the drug to feel the same pain relief or other desired effects.
In other words, tolerance makes the drug seem less effective to your body.
How quickly you develop codeine tolerance depends on factors such as:
your genetics
how long you’ve been taking the drug
how much of the drug you’ve been taking
your behavior and perceived need for the drug
So Larry is taking like six tablets a night by now? No wonder he lives alone in a Housing Commission flat—even on prescription (doubt it) that is quite a cost, 2-3 packets a week!
Quote:Dependence
As your body becomes more tolerant of codeine, your cells begin relying on the drug to prevent withdrawal symptoms.
This is dependence. It’s what leads to intense withdrawal side effects if codeine use is stopped suddenly. One sign of dependence is feeling that you must take codeine to prevent withdrawal symptoms.
Dependence can occur if you take codeine for more than a few weeks or if you take more than the prescribed dosage.
It’s also possible to develop codeine dependence even if you take the drug exactly as your doctor prescribes.
Dependence is often a part of addiction, but they’re not the same.
I was skirting on the edge of dependence with the Endones prescribed and supplied to me after my hip replacement operation—stopped in time. I had quit smoking and did not want another addiction! 21 Endones Annie and me calculated I had taken and dependence is 30 doses apparently. If I had given in and taken that 22nd Endone well, dependency and addiction not far away!
Quote:Dependence and addiction both cause withdrawal when the drug is stopped, but they’re not the same thing.
Dependence stems from long-term exposure to a drug, and people dependent on a drug will experience mild or severe withdrawal symptoms when they abruptly stop taking the drug.
Physical dependence on a prescribed opiate is a typical response to treatment and can be managed with help from your doctor.
Addiction, on the other hand, may follow dependence. It involves craving and compulsively seeking the drug. Addiction can change your brain circuitry, leading you to use a drug despite negative consequences and eventually to lose control over your usage. It often requires more support to get through.
“Can be managed with help from your doctor.” What if you didn’t get it on a prescription from a doctor? Who will help[ you then? I guess you go on until you are sent to drug rehab. Larry was missing for quite a while not so long ago, remember?
Quote:Withdrawal symptoms may come in two phases. The early phase occurs within a few hours of your last dose. Other symptoms may occur later as your body readjusts to working without codeine.
Early symptoms of withdrawal may include:
feeling irritable or anxious
trouble sleeping
teary eyes
runny nose
sweating
yawning
muscle aches
faster heart rate
Later symptoms may include:
loss of appetite
nausea and vomiting
stomach cramps
diarrhea
enlarged pupils
chills or goosebumps
Many withdrawal symptoms are a reversal of codeine side effects.
For instance, codeine use can cause constipation. But if you’re going through withdrawal, you may develop diarrhea. Likewise, codeine often causes sleepiness, and withdrawal may lead to trouble sleeping.
How long withdrawal lasts
Symptoms may last for a week, or they may persist for months after stopping codeine use.
Physical withdrawal symptoms are strongest in the first few days after you stop codeine use. Most symptoms are gone within 2 weeksTrusted Source.
However, behavioral symptoms and cravings for the drug can last months. In rare cases, they can even last years. Everyone’s experience with codeine withdrawal is different.
https://www.healthline.com/health/codeine-withdrawal#treatmentThe article goes further but the above is all we need. Do NOT take Mersyndal “every night.” Just now and then when you have severe pain.