https://edition.cnn.com/2026/04/05/business/plus-size-clothing-glp1sPlus-size fashionistas worry GLP1-s will make it even harder for them to shop
By
Ramishah Maruf
Apr 5, 2026
GLP-1 (glucagon-like peptide-1) receptor agonists are a class of medications that mimic a natural hormone to manage type 2 diabetes and promote significant weight loss (10-15%) by lowering blood sugar, slowing gastric emptying, and reducing appetite. Popular, approved medications include Ozempic (semaglutide), Wegovy, and Victoza.

New York — Buying clothes has always been challenging for Ann Lindsay.
As a plus-sized 41-year-old, she finds many stores’ plus-size offerings too matronly or too expensive.
Lately, it’s gotten worse: Last month, she noticed that her local Target in Chicago removed plus sizes entirely. There were significantly fewer options online, too.
In the pre-Covid era, big box retailers pushed inclusive sizing with fanfare. (“Whatever the tag says, you’re always a size YES to us,” Old Navy proclaimed in a massive campaign in 2018.)
But now plus-size shoppers say inclusive sizing is dwindling, as the rise of GLP-1s fuels worries about a return of skinny culture – a fashion and culture resurgence in thinness.
“I see the direction of skinny culture,” Lindsay said. “Brands are just falling right in line with what they think people want.”
Plus-size clothing in the United States generally starts at size 14 or 16 for women.